Wellbutrin XL (Buproprion) Patient Information

Find out why Wellbutrin is prescribed, side effects of Wellbutrin, Wellbutrin warnings, effects of Wellbutrin during pregnancy, more - in plain English.

Generic name: Bupropion hydrochloride
Brand names: Wellbutrin SR, Wellbutrin XL

Pronounced: Well-BEW-trin

Wellbutrin XL (buproprion) Full Prescribing Information
Wellbutrin XL Medication Guide

Why is Wellbutrin prescribed?

Wellbutrin, a relatively new antidepressant medication, is given to help relieve certain kinds of major depression.

Major depression involves a severely depressed mood (for 2 weeks or more) and loss of interest or pleasure in usual activities accompanied by sleep and appetite disturbances, agitation or lack of energy, feelings of guilt or worthlessness, decreased sex drive, inability to concentrate, and perhaps thoughts of suicide.

Unlike the more familiar tricyclic antidepressants, such as Elavil, Tofranil, and others, Wellbutrin tends to have a somewhat stimulating effect.

The drug is available in regular and sustained-release formulations (Wellbutrin SR).

Most important fact about Wellbutrin

Although Wellbutrin occasionally causes weight gain, a more common effect is weight loss: Some 28 percent of people who take this medication lose 5 pounds or more. If depression has already caused you to lose weight, and if further weight loss would be detrimental to your health, Wellbutrin may not be the best antidepressant for you.

How should you take Wellbutrin?

Take Wellbutrin exactly as prescribed by your doctor. The usual dosing regimen is 3 equal doses spaced evenly throughout the day. Allow at least 6 hours between doses. Your doctor will probably start you at a low dosage and gradually increase it; this helps minimize side effects.

You should take Wellbutrin SR, the sustained-release form, in 2 doses, at least 8 hours apart. Swallow Wellbutrin SR tablets whole; do not chew, divide, or crush them.


If Wellbutrin works for you, your doctor will probably have you continue taking it for at least several months.

--If you miss a dose...

Take it as soon as you remember. If it is within 4 hours of your next dose, skip the one you missed and go back to your regular schedule. Never take 2 doses at the same time.

--Storage instructions...

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Store at room temperature. Protect from light and moisture.

What side effects may occur when taking Wellbutrin?

Side effects cannot be anticipated. If any develop or change in intensity, inform your doctor as soon as possible. Only your doctor can determine if it is safe for you to continue taking Wellbutrin.

Seizures are perhaps the most worrisome side effect.

  • More common side effects of Wellbutrin may include: Abdominal pain (Wellbutrin SR), agitation, anxiety (Wellbutrin SR), constipation, dizziness, dry mouth, excessive sweating, headache, loss of appetite (Wellbutrin SR), nausea, palpitations (Wellbutrin SR), vomiting, skin rash, sleep disturbances, sore throat (Wellbutrin SR), tremor

  • Other side effects of Wellbutrin may include: Acne, allergic reactions (severe), bed-wetting, blisters in the mouth and eyes (Stevens-Johnson syndrome) blurred vision, breathing difficulty, chest pain, chills, complete or almost complete loss of movement, confusion, dry skin, episodes of over-activity, elation, or irritability, extreme calmness, fatigue, fever, fluid retention, flu-like symptoms, gum irritation and inflammation, hair color changes, hair loss, hives, impotence, incoordination and clumsiness, indigestion, itching, increased libido, menstrual complaints, mood instability, muscle rigidity, painful ejaculation, painful erection, retarded ejaculation, ringing in the ears, sexual dysfunction, suicidal ideation, thirst disturbances, tooth ­ache, urinary disturbances, weight gain or loss

Why should this drug not be prescribed?

Do not take Wellbutrin if you are sensitive to or have ever had an allergic reaction to it.

Since Wellbutrin causes seizures in some people, do not take it if you have any type of seizure disorder or if you are taking another medication containing bupropion, such as Zyban, the quit smoking aid. If you have a seizure while taking Wellbutrin, stop taking the drug and never take it again.

Do not take Wellbutrin while abruptly giving up alcohol or sedatives, including tranquilizers such as Librium, Valium, and Xanax. Rapid withdrawal increases the risk of seizures.

If you have had any kind of heart trouble or liver or kidney disease, be sure your doctor knows about it before you start taking this drug. It must be used with extreme caution if you have severe cirrhosis of the liver. A reduced dosage may be needed if you have any sort of liver or kidney problem.

You should not take Wellbutrin if you currently have, or formerly had, an eating disorder. For some reason, people with a history of anorexia nervosa or bulimia seem to be more likely to experience Wellbutrin-related seizures.

Do not take Wellbutrin if, within the past 14 days, you have taken a monoamine oxidase inhibitor (MAO inhibitor) drug, such as the antidepressants Marplan, Nardil or Parnate. This particular drug combination could cause you to experience a sudden, dangerous rise in blood pressure.

Special warnings about Wellbutrin

All antidepressants carry an FDA warning about the possibility of causing suicidal thoughts or behaviors in children, adolescents and even adults. More info on that here.

If you take Wellbutrin, you may be vulnerable to seizures if your dosage is too high or if you ever suffered brain damage or experienced seizures in the past.

Stop taking Wellbutrin and call your doctor immediately if you have difficulty breathing or swallowing; notice swelling in your face, lips, tongue, or throat; develop swollen arms and legs; or break out with itchy eruptions. These are warning signs of a potential severe allergic reaction.

The danger of seizures is greater in people addicted to narcotics, cocaine, or stimulants, and in those using over-the-counter stimulants or diet pills. Alcohol abuse or withdrawal also increases the risk, as does the use of other antidepressants or major tranquilizers. The risk is higher, too, if you are taking insulin or oral diabetes medication.

Since Wellbutrin may impair your coordination or judgment, do not drive or operate dangerous machinery until you find out how the medication affects you.

Possible food and drug interactions when taking Wellbutrin

Do not drink alcohol while you are taking Wellbutrin; an interaction between alcohol and Wellbutrin could increase the possibility of a seizure.

If Wellbutrin is taken with certain other drugs, the effects of either could be increased, decreased, or altered. It is especially important to check with your doctor before combining Wellbutrin with the following:

Beta blockers (used for high blood pressure and heart conditions) such as Inderal, Lopressor, and Tenormin
Carbamazepine (Tegretol)
Cimetidine (Tagamet)
Cyclophosphamide (Cytoxan)
Heart-stabilizing drugs such as Rythmol and Tambocor
Levodopa (Larodopa)
Major tranquilizers such as Haldol, Risperdal,
Thorazine, and Mellaril
MAO inhibitors (such as the antidepressants Parnate and Nardil)
Nicotine patches such as Habitrol, NicoDerm CQ, and Nicotrol patch
Orphenadrine (Norgesic)
Other antidepressants such as Elavil, Norpramin, Pamelor, Paxil, Prozac, Tofranil, and Zoloft
Phenytoin (Dilantin)
Steroid medications such as Prednisone
Theophylline (Theo-Dur)

Special information if you are pregnant or breastfeeding

If you are pregnant or plan to become pregnant, notify your doctor immediately. Wellbutrin should be taken during pregnancy only if clearly needed.

Wellbutrin does pass into breast milk and may cause serious reactions in a nursing baby; therefore, if you are a new mother, you may need to discontinue breastfeeding while you are taking this medication.

Recommended dosage for Wellbutrin

No single dose of Wellbutrin should exceed 150 milligrams.



At the beginning, your dose will probably be 200 milligrams per day, taken as 100 milligrams 2 times a day. After at least 3 days at this dose, your doctor may increase the dosage to 300 milligrams per day, taken as 100 milligrams 3 times a day, with at least 6 hours between doses. This is the usual adult dose. The maximum recommended dosage is 450 milligrams per day taken in doses of no more than 150 milligrams each.

Wellbutrin SR

The usual starting dose is 150 milligrams in the morning. After 3 days, if you do well, your doctor will have you take another 150 milligrams at least 8 hours after the first dose. It may be 4 weeks before you feel the benefit and you will take the drug for several months. The maximum recommended dose is 400 milligrams a day, taken in doses of 200 milligrams each.

If you have severe cirrhosis of the liver, your dosage should be no more than 75 milligrams once a day. With less serious liver and kidney problems, the dosage will be somewhat reduced.


The safety and effectiveness in children under 18 years old have not been established.


Although they are more sensitive to antidepressant drugs, older people have responded no differently to Wellbutrin than younger people.


Any medication taken in excess can have serious consequences. If you suspect an overdose of Wellbutrin, seek medical attention immediately.

  • Symptoms of Wellbutrin overdose may include: Hallucinations, heart failure, loss of consciousness, rapid heartbeat, seizures

  • Symptoms of Wellbutrin SR overdose may include: Blurred vision, confusion, jitteriness, lethargy, light-headedness, nausea, seizures, vomiting

  • An overdose that involves other drugs in combination with Wellbutrin may also cause these symptoms: Breathing difficulties, coma, fever, rigid muscles, stupor

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Wellbutrin XL (buproprion) Full Prescribing Information
Wellbutrin XL Medication Guide

back to: Psychiatric Medication Patient Information Index

APA Reference
Staff, H. (2009, January 3). Wellbutrin XL (Buproprion) Patient Information, HealthyPlace. Retrieved on 2024, July 21 from

Last Updated: January 23, 2019

Medically reviewed by Harry Croft, MD

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